CENPE and cancer: Although the antitumor activity of GSK923295 is being evaluated clinically, preclinical studies have revealed that CENP-E mRNA expression does not correlate with sensitivity to the CENP-E inhibitor in cancer cells (Fig 6B and [24]), suggesting that CENP-E expression is not a feasible biomarker for predicting tumors that are sensitive to the CENP-E inhibitor.