NFKB1 and liver dysplastic nodule: (RLM), a commonly used TCM for the treatment of urinary tract infection and antioxidative treatment, could play a critical role in the pathogenesis of DN through increasing the activity of SOD and total antioxidant capacity, decreasing MDA and ROS levels, and inhibiting NF-κB p65 and MCP-1 expression following increased IκB protein expression in STZ induced diabetic rats; all the data suggested that RLM could be a therapeutic potential for DN [97].