TGFB1 and liver dysplastic nodule: XCHT has been shown to decrease the expression of TGF-β1, FN, and collagen IV accompanied with increased BMP-7 expression in STZ induced diabetic mice and HG stimulated RMC, which was mediated through decreasing oxidative stress and productions of TGF-β1, FN, and collagen IV in renal cortex during the development of DN [48].