Astragaloside IV (ASI) in radix astragali is considered to be an active constituents; ASI could inhibit human tubular epithelial cells apoptosis and reduce TGF-β1 expression, suggesting a new treatment for DN probably mediated by the inhibition of p38 MAPK pathway activation and HGF overproduction [113]. This evidence concerns the gene TGFB1 and liver dysplastic nodule.