In OLETF rats, HJG could reduce TGF-β1, FN, iNOS, and COX-2 expressions in kidney cortex, urinary protein excretion was decreased, Ccr levels were improved, and serum glycosylated protein and AGEs were reduced effectively; data mentioned above suggested that HJG has beneficial effect on the DN progression [30]. The gene discussed is FN1; the disease is liver dysplastic nodule.