Additionally, Chen et al. [17] claimed that circulating betatrophin levels were associated with markers of insulin resistance (HOMA-IR, quantitative insulin sensitivity check index (QUICKI), the Gutt insulin sensitivity index (ISIG) and the Matsuda insulin sensitivity index (ISIM)); however, correlation between betatrophin and HOMA2-IR or HOMA2-%S is not observed in our population. Here, ANGPTL8 is linked to Insulin resistance.