Both IL-6 and IGF-1 inhibit drug-induced apoptosis of MM cells through PI3K/AKT signaling and NF-κB activation, which in turn induces the intracellular expression of downstream inhibitor of apoptosis proteins (IAPs), FLICE-inhibitory protein (FLIP), survival, cellular inhibitor of apoptosis-2 (cIAP2), A1/BFL1, and X-linked inhibitor of apoptosis protein (XIAP) [32, 35, 110, 111]. Here, XIAP is linked to Miyoshi myopathy.