Other drugs, including cell signaling targeted therapies (PI3K/AKT/mTOR, p38 MAPK, Hsp90, Wnt, Notch, Hedgehog, and cell cycle) and strategies targeting the tumor microenvironment (hypoxia, angiogenesis, integrins, CD44, CXCR4, and selectins) are candidates for the treatment of refractory and relapse MM [220]. This evidence concerns the gene AKT1 and Miyoshi myopathy.