Chauhan et al. reported that combining PK-11195, an antagonist of the mitochondrial peripheral benzodiazepine receptors (PBRs), with bortezomib triggers synergistic anti-MM activity, even in MM cells resistant to doxorubicin, melphalan, thalidomide, dexamethasone, and bortezomib. Here, TSPO is linked to Miyoshi myopathy.