Potential therapies, including second-generation proteasome inhibitors, new immunomodulatory agents, DACi, and kinase inhibitors such as the mTOR inhibitor, as well as drugs targeting cytokine-related pathways, anti-PD-1/anti-PD-L1 monoclonal antibodies, and monoclonal antibodies (naked or conjugated with drugs), and CAR-T therapy, are under preclinical and clinical investigation to provide better treatment responses in MM patients. Here, MTOR is linked to Miyoshi myopathy.