IL6 and plasma cell myeloma: The predicted targets genes include genes involved in cell cycle regulation, cell growth, apoptosis, and the ubiquitin-conjugation pathways [115]. miR-21 targets Rho-B, PTEN, and BTG2 and controls STAT-3/IL-6-dependent pathways as well as AKT and NF-κB signaling via myeloma cell adhesion to BMSCs [117–119]. miR-21 inhibitor exhibits synergistic effects with dexamethasone, doxorubicin, and bortezomib [117], indicating that miR-21 may be involved in mediating drug resistance.