NFKB1 and neoplasm: Interestingly, natural polyphenols could induce apoptotic cell death in preneoplastic or neoplastic cells through various growth inhibitory mechanisms as the activation of cytochrome c and caspases, the arrest of cell cycle, and the modulation of signalling pathways (NF-κB, JAK/STAT) which result in the inhibition of tumour progression [15, 16].