ERCC6 and neoplasm: The frequency of the ERCC6 1097Val/Val genotype was significantly increased in muscle-invasive tumors as compared to non-muscle-invasive ones (p = 0.0045), and the similar trend concerned the Val allele frequency, which was almost doubled in patients with T2 tumors as compared to Ta neoplasms (37.5% and 20.9%, resp.; p = 0.0009).