Besides, isolated DNA samples were genotyped for polymorphism of DNA repair genes involved in BER and NER to elucidate both the possible impact of some other genetic variations (XPD Lys751Gln and ERCC6 Gly399Asp) on bladder cancer susceptibility and the association of all six polymorphisms with clinicopathological parameters of tumors for evaluating their prognostic relevance. The gene discussed is ERCC6; the disease is urinary bladder cancer.