The frequencies of homozygous wild type genotype of ERCC6 gene and heterozygous genotype of the OGG1 gene were significantly increased in LMP tumors, whereas the genotypes containing at least one variant allele of the ERCC6 gene occurred more often in patients with G3 or high grade urothelial carcinomas. The gene discussed is ERCC6; the disease is urothelial carcinoma.