In the latter case, cancer risk was mainly associated with the XPD 751Lys/Gln heterozygous genotype (OR (95% CI) = 1.36 (1.03–1.81) (p = 0.031)), which indicated that heterozygosity in this codon predisposes to tumorigenesis as it was earlier noticed for the XPD codon 312. Here, ERCC2 is linked to cancer.