POLB and colorectal carcinoma: In addition, the 242Pro/Pro genotype of the PolB gene in combination with the genotype 780Arg/His of LIG3 gene increases the risk of CRC (Table 7), and the risk is much higher than in case of the 780Arg/His SNP of LIG3 (OR = 2.154; 1.265–3.667, p = 0.004 versus OR = 1.570; 1.109–2.224, p = 0.011) (Table 4).