In case of gene-gene interactions between 589Lys/Glu EXO1 SNP and 780Arg/His LIG3 SNP, the simultaneous occurrence of Lys/Glu and Arg/His genotypes may increase risk of colorectal cancer (OR = 1.970 (1.041–3.731), p = 0.036) while concomitant presence of Glu/Glu and Arg/Arg genotypes may decrease the risk (OR = 0.402 (0.178–0.906), p = 0.026) (Table 6). Here, LIG3 is linked to colorectal cancer.