In our opinion, it is important to note interaction of polymorphisms 589Lys/Glu of the EXO1 gene and 780Arg/His of the LIG3 gene (Table 6), whose coexistence increases the risk of CRC compared to the presence of polymorphism 589Lys/Glu itself (OR = 1.970; 1.041–3.731, p = 0.036 versus OR = 1.570; 1.109–2.224, p = 0.011). The gene discussed is EXO1; the disease is colorectal carcinoma.