Recently researchers are interested in finding out whether other ‘omic’ technologies can also add to the information provided by genomics.14 Elevated levels of protein in biological fluid in cancer can be due to atypical secretion, shedding of membrane-associated proteins, change in cancer cells polarity, increased expression of proteases15 and single nucleotide polymorphism (SNP) of signal peptide,16 etc. HER2 is a cancer biomarker, and classic example of a membrane bound tyrosine kinase, that is shed into fluids. Here, ERBB2 is linked to cancer.