Prevalence of TP53 mutations in BRCA1 & 2 negative young Pakistani BC patients (≤ 30 years) was assessed, uncovering novel mutations which can account for a subset of cancers occurring in the younger age group.45 An association between vitamin D receptor Cdx-2 gene polymorphism and risk of breast cancer in premenopausal women revealed an increased risk of BC in young women with GG genotype,46 while another study reported a reduced expression of metastasis suppression genes (KiSS1 and KAL1) in Pakistani BC patients.47 Absence of FANCM c. This evidence concerns the gene KISS1 and breast cancer.