DISC1 and attention deficit-hyperactivity disorder: In the first and only existing study regarding the effect of DISC1 variants on ADHD, Jacobsen and colleagues reported the association of rs6675281 and rs11122330 polymorphisms with ADHD in 694 ADHD cases and 735 normal controls in Norwegian population.11 The detail In the ADHD case/control analysis by Jacobsen KK and coworker in 3013 found an association for the intronic DISC1 SNP, rs1538979 (OR: 1.33, 95% CI 1.03–1.73, P1⁄40.03), which was further strengthened using a Spanish cohort for replication (meta-analysis OR 1.25, P1⁄40.008 for the tested tag-SNP rs11122330).