DISC1 and psychiatric disorder: Disrupted-in-schizophrenia1 (DISC1) is a candidate gene causing susceptibility in a spectrum of psychiatric disorders.8DISC1 has the highest expression of brain tissue in the hippocampus and the cerebral cortex9 and have been implicated to be involved in neuronal migration, neurite outgrowth and axon targeting during brain development.10DISC1 is located on chromosome 1q42, and originally identified in a Scottish pedigree by observing a breakpoint causing a chromosomal translocation.