By treating patients with lympho-depleting agents (fludarabine and cyclophosphamide) followed by NK cell infusion and IL-2 fused with diphtheria toxin (IL-2DT), CD25+ cells are selectively depleted, leading to increased NK cell expansion and complete remission rate for patients with AML compared to regular IL-2 treatment (97). This evidence concerns the gene IL2 and acute myeloid leukemia.