The important involvement of TLR2 in pneumococcal meningitis was previously demonstrated in TLR2-deficient mice infected with S. pneumoniae serotype 3, showing an increase in the bacterial load and blood-brain barrier disruption (Echchannaoui et al., 2002; Koedel et al., 2003). This evidence concerns the gene TLR2 and pneumococcal meningitis.