APP and Dravet syndrome: While most common in hypertensive individuals, intracerebral hemorrhage has been reported in 20–50% of APP-Dup cases (Rovelet-Lecrux et al., 2006, 2007; Kasuga et al., 2009; Cohn-Hokke et al., 2012; McNaughton et al., 2012; Wallon et al., 2012), whereas individuals with DS are generally protected from this pathology.