DLG4 and neuroblastoma: In addition, Herzfeld et al. (2013) transfected human neuroblastoma cells with DSC3, a disease-specific sequence change within the TAF1/DYT3 multiple transcript system, and reported that this exerted a dramatic effect on overall gene expression including multiple genes involved in dopamine metabolism, with a significant decrease in DLG4 (PSD-95) expression.