In addition, since increased cerebrovascular permeability constitutes a significant pathologic factor in the development of other neurologic diseases, including seizures (Friedman et al., 2009) and traumatic brain injury (Shlosberg et al., 2010), and since tPA-mediated PDGFRα signaling has been implicated in regulation of vascular integrity in these diseases (Fredriksson et al., 2015; Su et al., 2015), our findings might be of importance not only for stroke but also for unrelated CNS disorders where vascular integrity is compromised. Here, PLAT is linked to Stroke.