In addition, since increased cerebrovascular permeability constitutes a significant pathologic factor in the development of other neurologic diseases, including seizures (Friedman et al., 2009) and traumatic brain injury (Shlosberg et al., 2010), and since tPA-mediated PDGFRα signaling has been implicated in regulation of vascular integrity in these diseases (Fredriksson et al., 2015; Su et al., 2015), our findings might be of importance not only for stroke but also for unrelated CNS disorders where vascular integrity is compromised. This evidence concerns the gene PLAT and nervous system disorder.