It has been reported that the repression of autophagy led to over-expression of p62/SQSTM1, which promoted tumor cell proliferation by various mechanisms such as regulating NF-κB signaling pathway, the accumulation of oxygen radicals, DNA damage and other processes (Kongara and Karantza, 2012; Moscat and Diaz-Meco, 2012). The gene discussed is SQSTM1; the disease is neoplasm.