However, the underlying mechanism in regarding to this inhibition may involve many aspects, such as EMAP II inhibited the growth of pancreatic cancer through inhibiting fibronectin-dependent proliferation (Schwarz et al., 2010a,b) or inhibited tumor angiogenesis by inducing endothelial cell apoptosis (Berger et al., 2000). The gene discussed is AIMP1; the disease is familial pancreatic carcinoma.