SIRT1 and acute respiratory distress syndrome: Therefore, we investigated the protecting effects of AC-Rsv on LPS-induced ARDS and the results revealed that AC-Rsv could reduce the mortality rate of mice challenged by LPS and attenuate lung injury by restricting leakage of fluid from blood vessels into pulmonary alveoli, inhibiting the concentration of cytokines and alleviating the abnormal expression of MAPK/SIRT1 expression induced by LPS.