Urokinase-type plasminogen activator receptor (uPAR) gene codes a serine protease that catalyzes the transformation of the inert zymogen plasminogen into plasmin [20, 71]. uPAR gene is upregulated by the activated RAS signaling pathway, the main signaling pathway activated in colon cancer [72]. This evidence concerns the gene PLG and malignant colon neoplasm.