LGALS1 and diabetes mellitus: In vivo, Lgals1 mRNA levels were significantly upregulated in the retina (diabetes at months 1, 2 and 6; EIU at day 1) and the RPE-choroid complex (CNV at day 4), compared to controls (Fig. 3D; Diabetes-1M, fold change = 0.89; Diabetes-2M, fold change = 12.83; Diabetes-6M, fold change = 38.62.