FGF21 and fatty liver disease: Our data demonstrate that: (i) HF‐diet induced hepatic steatosis is attenuated by exercise; (ii) Hepatic miR‐212 is upregulated in HF mice, while restored by exercise; (iii) miR‐212 is induced during lipogenesis in FFA‐treated HepG2 cells; (iv) miR‐212 upregulation induces, while miR‐212 downregulation reduces lipogenesis in HepG2 cells regardless of FFA treatment and (v) miR‐212 contributes to lipogenesis via targeting FGF‐21.