In MCF‐7 breast cancer cells, the apoptotic effect of platycodin D has been found to be associated with ROS generation, mitochondrial dysfunction, Bcl‐2 family protein modulation, caspase‐9, ‐8, ‐3 and PARP cleavage, stress‐activated MAPK proteins activation and ER stress. Here, BCL2 is linked to breast carcinoma.