The 9 common Smad3-associated DEGs in two CKD models were including 6 immunoglobulin genes (Ighg1, Ighg2c, Igkv12-41, Ighv14-3, Ighv5-6, and Ighg2b) and 3 metabolic genes (Ugt2b37, Slc22a19, and Mfsd2a). The gene discussed is IGHG1; the disease is chronic kidney disease.