The 9 common Smad3-associated DEGs in two CKD models were including 6 immunoglobulin genes (Ighg1, Ighg2c, Igkv12-41, Ighv14-3, Ighv5-6, and Ighg2b) and 3 metabolic genes (Ugt2b37, Slc22a19, and Mfsd2a). Here, SMAD3 is linked to chronic kidney disease.