SMAD3 and ganglioneuroma: The analysis of DEGs was shown in Fig. 1a and Table 2, compared to WT-Nor (Smad3 wild-type normal control) group, totally 2417 DEGs were found in WT-GBM (Smad3 wild-type anti-GBM GN model) including 1552 up-regulated and 865 down-regulated DEGs which accounting for 64.21% and 35.79% of the total DEGs.