In rats with myocardial infarction, intramyocardially injection of exogenous HMGB1 attenuates cardiomyocyte hypertrophy in non‐infarcted segment and improves global cardiac function 9, while HMGB1 blockade by neutralizing anti‐HMGB1 antibody results in thinning and expansion of the infarct scar and marked hypertrophy of the non‐infarcted area 10. This evidence concerns the gene HMGB1 and myocardial infarction.