Two SNPs were replicated in the study, one in the known epilepsy gene SCN1A and another in a transmembrane protein of as yet unclear function, ANO3. Two further SNPs were associated overall but not replicated, one in SCN2A and the other in a non-coding region implicated as a quantitative trait loci for serum Mg2+ levels. The gene discussed is ANO3; the disease is epilepsy.