Among the 17 target genes down-regulated in inflamed large-IECs (Table 4), only 3 (17.6%) are known to be IBD-related: ABCG2 (ATP-binding cassette transporter G2), AQP8 (aquaporin 8), and SELENBP1 (selenium binding protein 1)35, 36, 37. Here, AQP8 is linked to inflammatory bowel disease.