Of the 18 mRNA targets up-regulated in inflamed large-IECs, 9 (CCL3, TREM1, NCF4, CXCL9, NCF2, SLC11A1, CD97, SFPQ, and CXCL16) were revealed to correlate with results from previous studies of IBD (Table 3)17, 18, 19, 20, 21, 22, 23, 24, 25. The gene discussed is TREM1; the disease is inflammatory bowel disease.