For example, miR‐15b, miR‐16 and miR‐497 were found to be down‐regulated in multidrug‐resistant gastric cancer cell line SGC7901/VCR (vincristine) and overexpression of these miRNAs could sensitize cells to anti‐cancer drugs by targeting anti‐apoptotic gene BCL2 8, 28; Colon cancer stem‐like cell populations, which are highly resistant to 5‐FU treatment, contained high level of miR‐140 and inhibition of miR‐140 activity sensitized these stem‐like cells to 5‐FU treatment by targeting HDAC4 29. Here, HDAC4 is linked to malignant colon neoplasm.