BCP A1762T/G1764A double mutants increase the risk of liver cirrhosis and hepatocellular carcinoma (HCC)5, 6, 7, 8, 9, PC G1896A mutant decreases the risk of HCC6, although the impact of PC G1896A mutant on HCC development remain controversial. The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.