The fused product consists of exons coding most of the RasGAP domain and the intact RasGAP C terminus domain of IQGAP3, while retained exon 1 and exon 2 of TMC6. RNA-seq data revealed markedly higher, outlier expression of IQGAP3 in primary and metastasis tumour of patient WG04, and investigation of reads coverage indicated that highly covered regions were enriched in exons containing RasGAP and RasGAP C terminus domains (Supplementary Fig.17b,c). This evidence concerns the gene TMC6 and neoplasm.