An inter-chromosomal rearrangement occurred between chromosome 17 and chromosome 1 was identified in patient WG04, in both primary and metastasis tumours, which results in a novel gene–gene fusion involving TMC6 and IQGAP3, with reversed 5′ and 3′ orientation (Supplementary Fig. 17a). Here, IQGAP3 is linked to neoplasm.