RASA2 and neoplasm: No significant difference was observed in IQGAP3 expression between tumours and normal tissues in the eight cases carrying somatic mutations, including four mutated sites located in the Ras GTPase-Activating Protein (RasGAP) domain (Q1085H, A1124T, D1164E and L1292 splicing site) and one truncated mutation that resulted in the loss of the RasGAP C terminus domain (Fig. 4b).