The result is consistent with previous studies showing a cardioprotective effect ofGH on the synthesis of type I and III collagen during pathological cardiacremodeling.20,21 In rats with ventricular hypertrophy induced by chronicpressure overload, GH induced a cardioprotective effect, attenuating myocardialfibrosis.21 However, notanalyzing the collagen type (IαI, IαII and III) was a limitation of ourstudy, because it can vary according to the type of stimulus (physiological orpathological), and with the supplementation of substances and exercise intensity. This evidence concerns the gene GH1 and Ventricular hypertrophy.