Our data suggest that hepatic mIndy is an interesting target for the treatment of NAFLD and type 2 diabetes and first selective mINDY (SLC13A5) inhibitors have shown promise in this regard (40)Further studies need to address the important question whether or not the knockdown of mIndy in mammals will also promote longevity. The gene discussed is SLC13A5; the disease is metabolic dysfunction-associated steatotic liver disease.