AKT1 and nervous system disorder: Considering the results already presented and taking into account the contribution of GSK-3β to the development and progression of many neurological diseases due to its regulation in neuroinflammatory processes [83], it was possible to observe an age-related decrease in the pGSK-3β/GSK-3β ratio in 12- and 24-month-old rats (Fig. 4) accompanied by the decrease in the phosphorylation ratio of the upstream protein AKT (Ser 473) at 24-month-old rat in comparison to the 4-month-old group (Fig. 3).