Furthermore, the N-terminal region of PfEMP1 IT4-VAR19 comprising a full-length DC8 cassette as well as the single EPCR binding domain CIDRα1.1, produced as recombinant proteins, were used to analyse their recognitions by plasma IgG from Beninese children presenting acute mild malaria, severe malaria or cerebral malaria at the time of their admission to the clinic and 30 days later. This evidence concerns the gene PROCR and malaria.