The evaluation of the antigenic relationship of DC8-PfEMP1 variants, was assessed by quantifying the levels of naturally acquired antibody targeting the IT4-VAR19 full-length DC8 cassette, the single EPCR-binding CIDRα1.1 domain, the apical membrane antigen (AMA)-1 and full length VAR2CSA extracellular region, in plasma samples from Beninese children presenting either acute mild malaria (UM), severe malaria (SM) or cerebral malaria (CM) at the time of their admission to the clinic and from convalescent-phase sera collected 30 days after anti-malaria treatment (Fig. 6). This evidence concerns the gene PROCR and cerebral malaria.