In addition, cluster 7 “EF hand and calcium ion binding” (ES = 1.3) contains multiple genes shown to play an important role in cancer (S100A9, S100A2, CAPNS2, ANXA10, CRTAC1, FREM2, MMP7, PLA2G2A), including two members of the S100A family of proteins. This evidence concerns the gene S100A1 and cancer.