In addition, cluster 7 “EF hand and calcium ion binding” (ES = 1.3) contains multiple genes shown to play an important role in cancer (S100A9, S100A2, CAPNS2, ANXA10, CRTAC1, FREM2, MMP7, PLA2G2A), including two members of the S100A family of proteins. Here, FREM2 is linked to cancer.