To determine whether the association of glioma risk with genotypically-estimated LTL was due only to the previously established associations of glioma risk with SNPs near TERC, TERT and RTEL1, LTL estimates were re-calculated in the combined discovery and replication dataset using the other five LTL-associated SNPs located near genes that had not been previously associated with glioma risk (ACYP2, NAF1, OBFC1, CTC1 and ZNF208). This evidence concerns the gene RTEL1 and central nervous system cancer.