TERT and central nervous system cancer: In single-locus analyses of each of the eight LTL-associated SNPs, four of the eight SNPs were associated with glioma risk at P < 0.05, including: rs10936599 in TERC (O.R. = 1.14; 95% C.I. = 1.03-1.28; P = 0.014) and rs2736100 in TERT (O.R. = 1.39; 95%C.I.