Current guidelines provided by American Society of Clinical Oncology (ASCO) [8] and National Comprehensive Cancer Network (NCCN) (http://www.tri-kobe.org/nccn/guideline/lung/english/non_small.pdf) indicate that patient tumor samples must be positive for EGFR mutations to be eligible for TKI treatment. The gene discussed is EGFR; the disease is neoplasm.