We and others have shown that Fra-1 promotes metastasis through various molecules: ADORA2B [7] in breast cancer, MMPs in breast cancer [14] and in lung epithelial cells [15], CD44 in mesothelioma [16], AXL in bladder cancer [17], FAK and EZH2 in colon cancer [18], [19]. Here, CD44 is linked to breast carcinoma.