NAV2 and neoplasm: All newly discovered individual prognostic methylation biomarkers are part of the signature and further inspection of the other assays included in the signature shows biomarkers previously described in other tumor types, as well as genes previously linked to NB, such as NAV2, which functions in axonal elongation and is required for all-trans retinoic acid to induce neurite outgrowth in human NB cells [31].