TSC2 and neoplasm: However, there are reports showing NAA10 may repress tumorigenesis via two mechanisms: by decreasing cell proliferation and promoting autophagy by acetylating and stabilizing TSC2, a repressor of mTOR signaling, or by preventing tumor cell migration and invasion by acetylating and deactivating myosin light chain kinase (MLCK), a Ca2+/calmodulin-dependent protein kinase [16, 26].