TLX2 and myocardial infarction: Several studies have shown impaired intracellular Ca2+ handling after MI due to altered expression and function of the NCX (sodium/calcium exchanger 1), Serca-2a (sarcoplasmic reticulum Ca+2 ATPase-2a), and phospholamban (PLP) in cardiomyocytes while these proteins are restored by ET [1, 20–22].