Consistently, hyperactivation of TGF-β signaling and low levels of E-cadherin were observed in NPC specimens, and were associated with lymph node metastasis status of patients, suggesting that TGF-β signaling might play an important role in the lymph node metastasis in NPC [5, 8, 30, 31]. Here, CDH1 is linked to nasopharyngeal carcinoma.