Importantly, we observed that TGF-β-induced luciferase activity and the EMT phenotype were robustly elevated in FLOT1-overexpressing NPC cells, but abrogated by silencing of FLOT1 (Figure 5A, 5C, 5D and Supplementary Figure 4A, 4B), suggesting that FLOT1 plays an important role in sensitizing NPC cells to EMT-inducing signals such as TGF-β. Here, FLOT1 is linked to nasopharyngeal carcinoma.