Interestingly, FLOT1 has been reported to be crucial for coordinated assembly of signaling complexes and signal transduction induced by TNF-α, EGF, HGF and IGF-l, suggesting that FLOT1 might play an important role in mediating the heterotypic signals originate in the tumor microenvironment [17, 23, 37, 38]. Here, TNF is linked to neoplasm.