To investigate the epigenetic regulation of enhancers in SETD2 mutated ccRCC, we integrated ChIP-seq data for H3K4me1 and H3K27ac from normal adult human kidney (Epigenome Roadmap) with our 5mC and H3K36me3 profiles for 786-O parental and SETD2 KO cells. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.