SETD2 and neoplasm: Since > 90% of ccRCCs have SETD2 LOH, but evidence that monoallelic loss of SETD2 impacts global levels of H3K36me3 is lacking [13], we identified tumor samples from the Cancer Genome Atlas (TCGA) KIRC dataset with biallelic inactivation from copy number loss and concurrent SETD2 mutation (n = 29) and compared these samples to KIRC tumors with no evidence of SETD2 mutation or LOH (n = 20).