In the primary tumor analysis it was difficult to rule out intratumoral heterogeneity or normal cell contamination as a cause for ectopic H3K36me3, however our 786-O isogenic model consistently shows overlapping ectopic H3K36me3 peaks with SETD2 mutant primary ccRCC, underscoring the validity of this finding. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.