For example, while the P50 is typically reported to be ~ −30 mmHg for heterologously expressed Piezo1 in HEK293t cells, in neural stem cells, the P50 was ~−13 mmHg, whereas the P50 was ~−40 mmHg in the breast cancer cell line MCF-7 (Coste et al., 2010; Li et al., 2014; Pathak et al., 2014). The gene discussed is PIEZO1; the disease is breast carcinoma.