APOE and atherosclerosis: Indeed, MMP-14 has been directly implicated in the migration/invasion of monocytes through the endothelium.10 We therefore assessed whether TIMP-2-dependent MMP-14 activity regulated the migration/invasion of monocyte/macrophages in vitro and in vivo, and therefore underlies the observed detrimental effects on atherosclerosis observed in TIMP-2−/− Apoe−/− mice.