Six were not consistent with a potential, IgE mediated allergic response as defined by international consensus criteria.21 Two participants reported skin symptoms (urticaria/angioedema) between 30 and 120 minutes after LAIV; both underwent subsequent specialist allergy testing four weeks later (to LAIV and excipients, all of which produced negative results) and were given a second dose of LAIV which was tolerated without any observed adverse symptoms in the two hours after vaccination. The gene discussed is IGHE; the disease is allergic disease.