Anaphylaxis to LAIV has been reported in adults (at a rate of 0.3 reactions per 100 000 doses), but none were related to egg allergy.28 We have previously reported that LAIV is unlikely to contain enough egg protein to trigger an IgE mediated allergic reaction in people with egg allergy.29 The risk of causing a systemic allergic reaction with quadrivalent LAIV therefore seems to be no greater in young people with egg allergy (including those with a history of anaphylaxis to egg) compared with those without egg allergy. This evidence concerns the gene IGHE and anaphylaxis.