A recent study showed that S100P staining identified IH‐CCs with bile duct morphology (a.k.a derived from the larger ducts of the biliary tree) to have a similar expression profile (CEA+, CK19‐9+, MUC2+, and more likely N‐Cadherin negative) to EH‐CC and PDAC 66. This evidence concerns the gene S100P and cholangiocarcinoma.