Moreover, inhibition of PI3K was proved to prevent the proliferation and differentiation of human lung fibroblasts into myofibroblasts in vitro and the PI3K inhibitors, WO2013117503 and WO2013117504 have been used to treat idiopathic pulmonary fibrosis in Phase I study 32, 33. The gene discussed is PIK3CA; the disease is pulmonary fibrosis.