In contrast, Deschwanden et al.13 reported the opposite tendency and a negative correlation between depressive symptoms, as assessed with the Beck Depression Inventory, and mGluR5 binding in all regions where DVR of [11C]ABP688 was decreased in MDD patients compared with controls (for example, in the parietal, temporal, frontal areas, thalamus and hippocampus). Here, GRM5 is linked to depressive symptom measurement.