No significant relationship was observed between the GADSS and binding in any region, despite the preclinical literature linking anxiety and mGluR5 (refs. 8, 54, 55, 56) and the use of mGluR5 antagonists as potential anxiolytics.57 However, the present study did demonstrate a significant positive correlation between MMSE score and DVR' of [11C]ABP688 in the left ventral striatum and bilateral caudate as well as between MoCA score and DVR' in right caudate. The gene discussed is GRM5; the disease is Anxiety.