ACE and Cognitive impairment: Indeed, acute and chronic cocaine administration induced a significant increase of ACE activity and gene expression in the rat prefrontal cortex and striatum, whereas ACE inhibitors showed a decrease in dopamine release.5, 6 Furthermore, both striatal and prefrontal function have been associated to performance on Hopkins delayed recall.77 Dopamine and glutamate systems manipulations can generate robust impairments in NOR.52 So, the dopamine-RAS78 interplay could explain ACE link to SCZ and cognitive deficits, representing it as a promising target to further investigation.