Reduced GABRB3 expression has been postulated in the pathogenesis of absence seizures, abnormal sensory processing, and other neurodevelopmental disorder phenotypes such as Angelman syndrome, autism spectrum disorders, and intellectual disability.8, 9, 10 Furthermore, single nucleotide polymorphisms and missense mutations in GABRB3 have previously been implicated in childhood absence epilepsy.11, 12. The gene discussed is GABRB3; the disease is autism spectrum disorder.