Thrombocytopenia has long been considered a valuable explanation for the bleeding tendency in VWD-type 2B patients, given the direct correlation between this bleeding condition and platelet counts.[4] GPIbα-VWF interactions having been reported to induce apoptotic events in platelets, we have explored the possibility that apoptosis contributed to VWD-type 2B thrombocytopenia.[8, 9]. This evidence concerns the gene VWF and Thrombocytopenia.