VWF and Thrombocytopenia: We have thus looked for apoptosis in platelets isolated from two patients with a severe VWF-type 2B mutation (VWF/p.V1316M) and from a mouse model expressing the same mutation.[10] Our data strongly argue in favor of the conclusion that apoptosis is not involved in thrombocytopenia observed in patients with VWD-2B or in mice expressing high levels of mVWF/p.V1316M.