von Willebrand factor (VWF) is a multimeric glycoprotein essential for primary hemostasis.[1] Indeed, platelet adhesion is initiated by the interaction of VWF with the platelet glycoprotein Ib-IX-V (GPIb-IX-V) receptor complex whereas stable adhesion requires the interaction of VWF with the integrin αIIbβ3.[2] The physiological role of VWF is illustrated in patients with the von Willebrand disease (VWD), which is characterized by a bleeding tendency. This evidence concerns the gene VWF and Von Willebrand disease.