Note that for P2 platelets no depolarization of ΔΨm in blood (Fig 2B: 2.9% ± 0.2%) and no caspase 3 activation (Fig 3) were detected, strongly suggesting that the apparent increased PS expression in P2 platelets in whole blood is the likely consequence of the more pronounced thrombocytopenia, compared to P1: this is strongly suggested by the fact that in washed platelets and normalized counts, no PS exposure was detected on P2 platelets. Here, CASP3 is linked to Thrombocytopenia.