First, thrombocytopenia may originate from impaired platelet production since VWD VWF appears to alter megakaryopoiesis.[5] In a second mechanism, thrombocytopenia may originate from the incorporation of platelets into circulating VWF/platelets aggregates [6] and increased clearance of platelets.[7] A third putative mechanism is platelet apoptosis. Here, VWF is linked to Thrombocytopenia.