TLR4 and myocardial infarction: In contrast, one study found that men with the 299Gly TLR4 genotype had an increased risk of myocardial infarction (MI) (Edfeldt et al., 2004), while other reports showed no obvious association between 299Gly and CAD (Morange et al., 2004; Zee et al., 2005; Koch et al., 2006; O’Halloran et al., 2006; Nebel et al., 2007; Beijk et al., 2010; Džumhur et al., 2012; Martínez-Ríos et al., 2013; Golovkin et al., 2014; Guven et al., 2015).